Arsenal who suffered a scare to progress against Ostersunds in the round of 32 – will travel to the San Siro for the first leg on Thursday, March 8.
The second leg takes place at the Emirates Stadium the following week on Thursday, March 15.
It is the standout tie of the last-16 but Arsene Wenger will be hoping his side have enough in the tank to progress to the quarter-final stage.
Meanwhile, Chelsea loanee Michy Batshuayi will face Salzburg after Borussia Dortmund drew the Austrian club.
Europa League last-16 draw
It might initially look like a tough tie for Arsenal but Milan aren’t the dominant force of Italian football they once were.
They are currently seventh in the Serie A table with 41 points from 25 games – 25 points behind leaders Napoli.
Last summer’s splurge in the transfer market hasn’t quite paid dividends but they’re starting to hit some form under Gennaro Gattuso.
Europa League last-16 draw
Dynamo Kiev vs Lazio
Leipzig vs Zenit
Atletico Madrid vs Lokomotiv Moscow
CSKA Moscow vs Lyon
Marseille vs Athletic Bilbao
Sporting Lisbon vs Plzen
Borussia Dortmund vs Salzburg
AC Milan vs Arsenal
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